"Single Cell Monitoring of Growth Arrest and Morphological Changes Induced by Transfer of Wild-Type p53 Alleles to Glioblastoma Cells."

According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "Mutation of the p53 tumor suppressor gene is one of the earliest identified genetic lesions during malignant progression of human astrocytomas. To assess the functional significance of these mutations, wild-type (WT) p53 genes were introduced into glioblastoma cell lines having mutant, WT, or null endogenous p53 alleles. Populations of cells with mutant or null endogenous p53 alleles and exogenous WT p53 were spontaneously selected in culture for cells expressing only mutant p53 or no p53, which then displayed a growth and tumorigenic phenotype...

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