NSCLC

Tumor Suppressor Protein Shows Promise as Efficient Cancer Therapeutic

Published in Cancer Weekly, April 3rd, 1995

California researchers show that the introduction of wild-type retinoblastoma (RB) protein into RB^neg tumor cells suppresses their growth.

Douglas Antelman et al., of Canji Inc., remark that the tumor suppressor gene, RB, has been the subject of intensive study as it seems to play a central role in regulating normal cellular growth. Biological consequences of RB inactivation include alterations in cellular differentiation, uncontrolled cell proliferation and the genesis of several types of tumors.

Antelman et al. report "Since many cancers are characterized by RB mutation, restoring wild-type RB function to...

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Source: Cancer Weekly (1995-04-03)

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