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Transplantation/Stem Cells

Less Severe Conditioning May Work for Modified Cell Engraftment

Published in Cancer Weekly, April 10th, 1995

Cancer researchers stated that their findings suggest that myeloablative or myelosuppressive conditioning improves engraftment of genetically marked stem cells.

The question whether the engraftment of hematopoietic stem cells requires the conditioning of the host has remained controversial.

Jorge Barquinero, Fred Hutchinson Cancer Research Center, Seattle, Washington, and colleagues, set out to find whether it is possible to engraft transduced hematopoietic stem cells through using no conditioning or using less toxic conditioning regimens ("Myelosuppressive Conditioning Improves Autologous Engraftment of Genetically Marked Hematopoietic Repopulating...

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