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Telomeres, Telomerase and Potential Therapeutic Uses

Published in Cancer Weekly, April 17th, 1995

Dr. Jerry W. Shay, from the University of Texas Southwestern Medical Center at Dallas, presented an overview of the research being done on telomeres and the protein telomerase, and a view of the potential uses of this knowledge in the world of cancer therapeutics at the American Cancer Society's 37th Science Writers Seminar, March 29, 1995.

Briefly, he described telomeres as the "clock" that appears to regulate how much an individual cell can divide. Telomeres, the repeated DNA sequences found at the ends of chromosomes, shorten each time a cell divides. When the telomeres reach a critically short length, the cell stops dividing and ages (senesces) and cellular...

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