Published in Cancer Weekly, June 12th, 1995
Normal prostate tissue and as well as prostate cancer depend on androgens for their development. Androgens act through the androgen receptor. Once bound to androgen, the androgen receptor regulates the expression of androgen-responsive genes by interacting with transcription factors and by binding to their androgen-responsive elements.
Metastatic prostate cancer can be treated with response rates up to 80% by androgen ablation, but the duration of the response is...
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