Pathogenesis

Telomerase Activity Activated Late in Hematologic Malignancies

Published in Cancer Weekly, July 17th, 1995

Short telomere length, despite detectable telomerase activity, suggests that selection for telomerase activation is a relatively late event in carcinogenesis.

Many different cancers exhibit short, or critically short, telomeres. Previous research has shown telomerase activity in metastatic ovarian carcinoma which stabilizes the short telomeres preserving the cancer cell integrity.

In order to reach the short, or critically short stage, these cancer cells must have already undergone several cell divisions. Christopher M. Counter et al. investigated the temporal pattern of telomerase expression in two hematologic malignancies with different...

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Source: Cancer Weekly (1995-07-17)

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