Antisense Technology

Oligodeoxynucleotides To Purge Bone Marrow in CML

Published in Cancer Weekly, July 31st, 1995

With additional fine tuning, targeted antisense oligodeoxynucleotides to bcr-abl have the potential to be used as ex vivo purging agents for use with autologous bone marrow transplantation in the treatment of chronic myeloid leukemia (CML).

CML is a neoplastic disorder of the hematopoietic stem cell in which the leukemic cells have a specific chromosomal defect termed the Philadelphia (Ph) chromosome. This chromosome is characterized by a translocation that results in the fusion of c-abl and the major bcr genes. The BCR-ABL tyrosine kinase has enhanced activity over wild-type c-ABL and is thought to play a central role in CML pathogenesis.

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Source: Cancer Weekly (1995-07-31)

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