Combination Therapies

Paclitaxel/Radiotherapy Sensitization: Will it Work for CNS Cancers?

Published in Cancer Weekly, July 31st, 1995

Paclitaxel does sensitize central nervous system (CNS) tumors to radiotherapy in in vitro experiments but does this application work in vivo'

Pharmacokinetic studies have shown that the blood-brain barrier is mighty indeed. In order for the radiosensitizing effect of paclitaxel to work for CNS tumors, it must first reach these tumors.

Michael J. Glantz et al. examined paclitaxel concentrations in the cerebrospinal fluid (CSF) of patients with CNS malignancies and in normal and malignant tissues from rat brains and compared them to concomitant plasma concentrations in order to determine if paclitaxel crosses the blood-brain barrier in high enough...

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Source: Cancer Weekly (1995-07-31)

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