Published in Cancer Weekly, August 14th, 1995
Paclitaxel has been shown to be active against carcinomas of the ovary, breast, lung and head and neck. The agent induces irreversible polymerization of microtubules and its cellular target is therefore similar to that of vinca alkaloids.
Because vinca alkaloids have been shown to have activity against Kaposi's sarcoma, researcher Robert Yarchoan and colleague investigated the use of paclitaxel against this condition in a group of AIDS patients ("Treatment of HIV-Associated Kaposi's Sarcoma...
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