"Distribution of Monoclonal Antibodies in Secretions of Mice with IgA and IgG Hybridoma Tumors."

According to an abstract submitted by the authors to the 8th International Congress of Mucosal Immunology, held July 17-20, 1995, in San Diego, California, "Mice bearing IgA hybridoma 'backpack' tumors have been used to show that secretion of monoclonal IgA can protect against mucosal infection, but the relevance of this model to normal IgA protection is not clear. We thus analyzed the distribution of specific monoclonal and total antibodies in bile, local intestinal secretions, vagina, urine and feces of mice bearing anti-cholera toxin (Cr) IgA and IgG backpack tumors; with and without bile duct ligation. Backpack tumors resulted in high levels of both anti-CT and total IgA or IgG in...

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