Cancer Gene Therapy
"Gene Therapy for Hepatoma Cells using a Retrovirus Vector Carrying Herpes Simplex Virus Thymidine Kinase Gene Under the Control of Human Alpha-Fetoprotein Gene Promoter."
Published in Cancer Weekly, August 28th, 1995
According to the authors' abstract of an article published in Cancer Research, "The alpha-fetoprotein (AFP) gene is normally expressed in fetal liver and is transcriptionally silent in adult liver but is reactivated in hepatocellular carcinoma. It has been shown that the positive and negative transcriptionally regulatory elements of the human AFP gene, which play an important role in its developmental regulation, exist over the quite extended region (4 kb). We constructed a hybrid gene consisting of herpes simplex virus thymidine kinase (HSV-tk) gene under the control of the 0.3-kb human AFP gene promoter and inserted it into a retroviral vector. When AFP-producing hepatoma cells were...
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Source: Cancer Weekly (1995-08-28)
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