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Anemia

Gene Therapy Provides Opportunity for Long-Term Treatment

Published in Cancer Weekly, September 4th, 1995

The long-term treatment of anemia associated with chronic renal failure, cancer, hemophilias and HIV infections could be possible with in vivo gene transfer of recombinant human erythropoietin (Epo).

The availability of recombinant human Epo has decreased the need for transfusion therapy of anemia (with its attendant dangers). A report by Spivak et al. (Hematology/Oncology Clinics of N. America, 1994;8(5):863-1043) noted that treatment with recombinant human Epo, given two to three times weekly, raised hemoglobin and hematocrit levels and improved cardiovascular status in the patients who received it.

William R.A. Osborne et al. reflected that the...

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