Immunotherapy
Tumor Regression and Rechallenge Immunity with Adenoviral Gene Transfer
Published in Cancer Weekly, September 25th, 1995
Research has shown that cancers often lack the secondary costimulatory signals required to produce the cytokines necessary to stimulate the host's immune system against the tumor. Adding exogenous cytokines has produced some successes toward overcoming the anergy of the host immune effector cells.
Christina L. Addison et al. sought an effective method of achieving high concentrations of the cytokine IL-2 by using an adenoviral gene delivery system to express IL-2 continuously around and within the tumor ("Intratumoral Injection of an Adenovirus...
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Source: Cancer Weekly (1995-09-25)
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