Cancer Vaccines
"Induction of Antigen-Specific Cytolytic T Cells In Situ in Human Melanoma by Immunization with Synthetic Peptide-Pulsed Autologous Antigen Presenting Cells."
Published in Cancer Weekly, September 25th, 1995
According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "Human melanoma cells can process the MAGE-1 gene product and present the processed nonapeptide EADPTGHSY on their major histocompatibility complex class I molecules, HLA-A1, as a determinant for cytolytic T lymphocytes (CTLs). Considering that autologous antigen presenting cells (APCs) pulsed with the synthetic nonapeptide might, therefore, be immunogenic, melanoma patients whose tumor cells express the MAGE-1 gene and who are HLA-A1+ were immunized with a vaccine made of cultured autologous APCs pulsed with the synthetic nonapeptide. ...
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Source: Cancer Weekly (1995-09-25)
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