Cancer Gene Therapy (Vectors)
Defective Herpes Simplex Viral Vector Successfully Transfers p53
Published in Cancer Weekly, October 9th, 1995
Countless research efforts have shown that mutations of the p53 tumor-suppressor gene in human cancers play a critical role in carcinogenesis and tumor suppression. In keeping with technological advancements, restoring normal p53 function with wt-p53 in neoplasms with several different gene therapy techniques has shown varying levels of success [(T.J. Liu et al., Cancer Research, July 15, 1995;55(14):3117-3122) and (Y.L. Hou et al., at the 1995 8th International...
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Source: Cancer Weekly (1995-10-09)
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