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Vectors

Adenovirus-Mediated Gene Transfer Preserves Normal Hepatic Function

Published in Cancer Weekly, October 9th, 1995

Liver function and integrity are not compromised following adenoviral-mediated gene transfer at therapeutic levels, researchers recently determined.

In vivo gene deliver via adenoviral vectors has been shown to have high therapeutic efficacy. However, the answer to the potential injurious effects of this treatment modality had not been fully answered with previous research.

Kenneth E. Drazan et al. examined liver function and markers of cell injury following adenovirus-mediated gene transfer in a rat model of sham orthotopic liver transplantation ("Hepatic Function is Preserved Following Liver-Directed, Adenovirus-Mediated Gene Transfer," Journal of...

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