Genetics
"Cytogenetics, Gene Fusions, and Cancer."
Published in Cancer Weekly, October 16th, 1995
According to the author's abstract of an article published in Annals of Clinical and Laboratory Science, "Cytogeneticists recognize that karyotypic abnormalities are associated with specific malignancies. In 1960, Nowell described the Philadelphia chromosome (Ph) and its relationship to chronic myelogenous leukemia (CML). Subsequent work in molecular genetics and biology has revealed that the Ph is a translocation that causes fusion of gene sites that code for the break cluster region (BCR) and the avian blastic leukemia (ABL) proteins. This so-called fusion protein is present in a large percentage of the patients who have CML. A related fusion protein is seen in about one third of...
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Source: Cancer Weekly (1995-10-16)
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