Animal Models

Murine Model Makes Applicable Advances for Human Gene Therapy

Published in Cancer Weekly, October 23rd, 1995

Better understanding of gene transduced murine totipotent cells leads to significant implications for future gene therapy trials.

Christine Richardson et al. transduced the human multiple drug resistance (MDR) gene into murine hematopoietic stem cells (HSCs) with a retroviral vector as a model system for potential human gene therapy ("Preselection of Transduced Murine Hematopoietic Stem Cell Populations Leads to Increased Long-Term Stability and Expression of the Human Multiple Drug Resistance Gene," Blood, October 1, 1995;86(7):2579-2589).

"The introduction of foreign genes into the HSCs of animals to follow the fate of HSCs should lead to a better...

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Source: Cancer Weekly (1995-10-23)

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