"Molecular Mechanisms of Cellular Drug Resistance."

According to an abstract submitted by the author to the Foundations of Leukemia Research: Promise for the Future Conference, sponsored by the Leukemia Research Foundation, held September 14-15, 1995, in Oakbrook, Illinois, "The killing of a leukemic cell by a chemotherapeutic drug is a complex multistep process. While some drugs can enter the cell by passive diffusion through the lipid bilayer of the plasma membrane, other agents require the presence of special carriers in the membrane for their entry. Some of the drugs are inactive in the form in which they enter the cell, and need to be activated through modification by appropriate cellular enzymes. An active drug inside the cell has...

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