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Cancer Gene Therapy
"Adenovirus-Mediated Gene Therapy of a Candidate Breast Tumor Suppressor Gene."
November 20th, 1995
According to an abstract submitted by the authors to the 4th International Conference on Gene Therapy of Cancer, held November 9-11, 1995, in San Diego, California, "H-Nuc is a candidate breast tumor suppressor gene which encodes an 824-amino acid protein. It was initially identified as CDC 27, the human homologue of Saccharomyces cerevisiae CDC 27, and mapped to human chromosome 17 q21-22, the same region as a candidate gene for early onset breast cancer (BRCA1). CDC 27 is a functional part of a complex which acts to ubiquitinate cyclin B. H-Nuc appears to bind hypophosphorylated Rb protein in the same region that SV40 large TAg binds. Conversely, Rb binds to...
Source: Cancer Weekly (1995-11-20)
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