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Tumor Suppressor Gene
"p56, a Truncated Form of RB, Functions as a More Potent Regulator of Cell Cycle Growth Than Full Length RB."
November 20th, 1995
According to an abstract submitted by the authors to the 4th International Conference on Gene Therapy of Cancer, held November 9-11, 1995, in San Diego, California, "p56, a truncated version of Rb beginning at amino acid number 379, is a more potent inhibitor of cell cycle progression than is the full-length Rb. p56 is able to repress the activity of a reporter gene consisting of the chloramphenicol acetyltransferase (CAT) gene driven by an adenovirus E2 promoter containing 2 E2F binding sites, to a greater extent than full length Rb. When recombinant adenoviruses expressing either full-length Rb or p56 were constructed and tested for growth suppression in several...
Source: Cancer Weekly (1995-11-20)
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