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Cancer Gene Therapy (Breast)
"Ligand-Directed Retroviral Targeting of Human Breast Cancer Cells."
November 20th, 1995
According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "We explored the feasibility of designing retroviral vectors that can target human breast cancer cells with characteristic receptors via ligand-receptor interaction. The ecotropic Moloney murine leukemia virus envelope was modified by insertion of sequences encoding human heregulin. Ecotropic virus, which normally does not infect human cells, when pseudotyped with the modified envelope protein now crosses species to infect human breast cancer cell lines that overexpress HER-2 (human epidermal growth factor receptor; also called ERBB2) and HER-4...
Source: Cancer Weekly (1995-11-20)
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