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Systemic Gene Transfer
"Systemic Gene Therapy: Biodistribution and Long-Term Expression of a Transgene in Mice."
November 20th, 1995
According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "We have investigated the in vivo efficacy of a systemic gene transfer method, which combines a liposomal delivery system (DLS liposomes) with episomally replicative DNA plasmids to effect long-term expression of a transgene in cells. A single i.v. injection of a plasmid DNA vector containing the luciferase gene as a marker was administered with the DLS liposomes in BALB/c mice. The luciferase gene and its product were found in all mouse tissues tested as determined by PCR analysis and immunohistochemistry. Luciferase activity was also detected...
Source: Cancer Weekly (1995-11-20)
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