Cancer Weekly
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Therapy (Monoclonal Antibodies)
"Phase I Trial of 2B1, a Bispecific Monoclonal Antibody Targeting c-erbB-2 and Fc gamma RIII."
November 20th, 1995
According to the authors' abstract of an article published in Cancer Research, "2B1 is a bispecific murine monoclonal antibody (BsMAb) with specificity for the c-erbB-2 and Fc gamma RIII extracellular domains. This BsMAb promotes the targeted lysis of malignant cells overexpressing the c-erbB-2 gene product of the HER2/neu proto-oncogene by human natural killer cells and mononuclear phagocytes expressing the Fc gamma RIII A isoform. In a Phase I clinical trial of 2B1, 15 patients with c-erbB-2-overexpressing tumors were treated with 1 h i.v. infusions of 2B1 on days 1, 4, 5, 6, 7, and 8 of a single course of treatment. Three patients were treated with daily doses of 1.0...
Source: Cancer Weekly (1995-11-20)
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