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Human Papillomavirus (Vaccine Design)

VLPs from One Variant May Help To Prevent Infection

Published in Cancer Weekly, December 25th, 1995

The finding that two human papillomavirus type 16 (HPV-16) variants are serologically cross-reactive is encouraging news for the development of a genital HPV vaccine.

Grace Cheng, U.S. National Cancer Institute, Bethesda, Maryland and colleagues from the U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, and the Danish Cancer Society, Copenhagen, Denmark, set out to find whether DNA sequence variants of HPV-16 are distinct serotypes.

Cheng et al. compared the reactivities of women's sera from Zaire (n=97) and Denmark (n=123) ("Divergent Human Papillomavirus Type 16 Variants Are Serologically Cross-Reactive," Journal of...

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