Cancer Gene Therapy (Prostate)
"Recombinant Adenovirus Vector Expressing Wild-Type p53 is a Potent Inhibitor of Prostate Cancer Cell Proliferation."
Published in Cancer Weekly, January 29th, 1996
According to the authors' abstract of an article published in Urology, "Objectives: A recombinant adenovirus vector (AdWTp53) expressing wild-type p53 was evaluated for its cell growth inhibitory effects on metastatic human prostate cancer cells. Methods: Human prostate cancer cells LNCaP, DU145, PC3, 1LN, and DUPro-1 were infected with AdWTp53 vector and expression of exogenous p53 in these cells was analyzed by immunoprecipitation and Western blot assays. The cell growth inhibitory effects of AdWTp53 were determined by counting cell number on a hemocytometer or by crystal violet staining of cells after infection with AdWTp53. The p53-regulated gene WAF1 and DNA...
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Source: Cancer Weekly (1996-01-29)
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