Gene Transfer (HSA)
Marker Gene Transduction Allows for Cell Selection Within 24 Hours
Published in Cancer Weekly, February 19th, 1996
The HSA gene encodes for a molecule that is normally expressed on the cell surface. It is the murine homologue of CD24 (a selectable marker), and would not normally be found on human cells.
Many gene therapy protocols could benefit from the ability to determine which cells have been successfully transduced. Most of the marker genes used to date, have been larger, and express themselves internally. HSA, being smaller (therefore taking up less space on the vector, and leaving more room for the therapeutic gene) as well as...
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Source: Cancer Weekly (1996-02-19)
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