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Vectors (Alternative)

Foamy Virus Examined for Gene Therapy Vector Potential

Published in Cancer Weekly, February 19th, 1996

Human foamy virus (HFV) may offer several potential advantages over currently available viral vectors.

There are three major subfamilies of retroviruses: lentiviruses, such as human immunodeficiency virus (HIV); oncoviruses, such as murine leukemia virus (MLV); and foamy viruses (or spumaviruses). Foamy viruses have been isolated in many vertebrates, and are thought to have originated in primates. They are not known to cause disease in humans. They have the largest genome size of all the retroviruses and their genomic RNA is 11,021 nucleotides in length.

David W. Russell et al. studied the transducing properties of HFV vectors and compared them...

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