"Vascular Integrins in Kaposi's Sarcoma Pathogenesis."

According to an abstract submitted by the author to the 3rd Conference on Retroviruses and Opportunistic Infections, held January 28 - February 1, 1996, in Washington, DC, "Kaposi's sarcoma (KS) is an angioproliferative disease particularly frequent in HIV-1-infected homosexual men. Recent data indicate that, at least in early phase, KS is an hyperplastic proliferative disease mediated by the cooperation of inflammatory cytokines, perhaps induced by the novel herpesvirus called HHV-8, and angiogenic factors. In this setting the Tat protein of HIV-1 increases the frequency and aggressiveness of KS by mimicking the effects of extracelluar matrix (ECM) proteins and heparin binding factors. ...

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