Cancer Gene Therapy

"Adenoviral-p53 Gene Transfer to Orthotopic and Peritoneal Murine Bladder Cancer."

Published in Cancer Weekly, February 26th, 1996

According to the authors' abstract of an article published in Journal of Urology, "Purpose: This study was designed to examine the potential for adenoviral-mediated gene therapy in primary and metastatic bladder cancer. Materials and Methods: Orthotopic and intraperitoneal bladder tumors were established after delivery of 1x10⁶ MBT-2 cells into syngeneic mice. Gene transfer was accomplished via intravesical or intraperitoneal instillation by using an E-1 deleted adenovirus encoding LacZ or human p53. Successful tumor transduction was confirmed in tumor DNA and mRNA by polymerase chain reaction. Detection of recombinant gene product was detected by...

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Source: Cancer Weekly (1996-02-26)

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