Vectors (Alphavirus)

Sindbis Virus DNA-Based Expression Vectors Show Broad Range Potential

Published in Cancer Weekly, February 26th, 1996

Modified Sindbis virus vectors show broad range potential for genetic immunization.

Several members of the Alphavirus genus have received attention for use as virus-based expression vectors. Alphaviruses have many properties which make them desirable alternatives to other virus-derived vector systems. They have a high-level expression of up to 10⁸ molecules of heterologous protein per cell, a broad host range and infectability of nondividing cells.

In contrast to retrovirus and adeno-associated virus-derived vectors, alphaviruses replicate entirely in the cytoplasm of the infected cell as an RNA molecule without a DNA...

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Source: Cancer Weekly (1996-02-26)

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