Disease Associations
"Immunoglobulin Gene Rearrangement Studies in African Patients with B-Cell Lymphoproliferative Disorders."
Published in Cancer Weekly, April 1st, 1996
According to an abstract submitted by the authors to the European Conference on Tropical Medicine, held October 22-26, 1995, in Hamburg, Germany, "Hyperactive malarial splenomegaly (HMS) results from a polyclonal expansion of lymphocytes in response to chronic malarial infection. In West Africa, the disease is often associated with a peripheral blood lymphocytosis, mimicking splenic Lymphoma with villous lymphocytes (SLVL) and African chronic Lymphocytic leukaemia (CLL). Some HMS patients develop unresponsiveness to antimalarial therapy. To investigate the hypothesis that HMS may evolve into a clonal lymphoproliferative disorder immunoglobulin heavy chain gene rearrangements were...
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Source: Cancer Weekly (1996-04-01)
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