"HLA Class II Expression in Melanoma: Implications for Immunotherapy."

According to an abstract submitted by the authors to the 49th Cancer Symposium of the Society of Surgical Oncology, held March 21-24, 1996, in Atlanta, Georgia, "HLA antigens are essential components of the specific arm of the immune system, presenting peptide antigens to T cells which then must differentiate self from non-self. While HLA class I antigens are ubiquitously expressed, constitutive expression of HLA class II antigens is normally restricted to professional antigen presenting cells of the immune system. Animal studies suggest that tumor cells made to express both HLA class I and class II molecules act as effective tumor vaccines. We asked whether induction of HLA class II...

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