"EBV-Specific T-Cell Immunity in AIDS Related NonHodgkin's Lymphoma."

According to an abstract submitted by the authors to the 37th Annual Meeting of the American Society of Hematology, held December 1-5, 1995, in Seattle, Washington, "The vast majority of AIDS-NHL are diffuse large-cell and immunoblastic lymphomas, thought to arise because of uncontrolled EBV-driven proliferation of B cells. Although EBV-specific CD8⁺ MHC class I-restricted cytotoxic T lymphocytes (CTL) are known to play a key role in EBV-specific immunity in healthy individuals, the mechanism of the defective EBV-immunosurveillance in HIV infection is largely unknown. The present study is aimed at two questions: 1) What is the temporal relationship between EBV-specific...

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