Vaccine Development
Poliovirus Pathogenicity Abolished by Rhinovirus Gene Insert
Published in Cancer Weekly, April 29th, 1996
The finding could lead to new vectors for DNA vaccines.
Vaccine strains of poliovirus are attenuated in the internal ribosomal entry site (IRES) of the viral genome. However, these strains retain neuropathogenic potential; indeed, they cause poliomyelitis in a very small number of human vaccinees.
Researchers Matthias Gromeier of the State University of New York at Stony Brook now report that by replacing the poliovirus IRES with that of rhinovirus (like polio, a member of the picornavirus family), the virus is rendered completely nonpathogenic.
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Source: Cancer Weekly (1996-04-29)
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