Conference Coverage (AACR)

Cancer Immunotherapy with Bacterial Superantigen Staphylococcal Enterotoxin A

Published in Cancer Weekly, May 6th, 1996

An immunoconjugate consisting of the bacterial superantigen Staphylococcal enterotoxin A (SEA) and a colon carcinoma monoclonal antibody induces cell surface leukocyte activation markers in colon carcinoma patients.

SEA is a potent T-cell specific mitogen that activates >10 percent of T cells following crosslinking of TCR V(beta) regions with MHC class II molecules. By combining SEA with the Fab-fragment of C242 monoclonal antibody which recognizes Le^A, a glycoprotein over-expressed in colon/pancreatic carcinomas, a recombinant E. coli-derived fusion protein labelled LS4565 was created.

Katherine Alpaugh, of the Fox Chase Cancer...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Cancer Weekly

Source: Cancer Weekly (1996-05-06)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry