Conference Coverage (AACR)

Production of IL-10 Localized to Melanoma Cells, Not Lymphocytes

Published in Cancer Weekly, May 6th, 1996

By localizing the production of IL-10 to melanoma cells, rather than in tumor infiltrating lymphocytes as previously suspected, novel avenues for potential therapeutic modalities may be created.

IL-10 is known to play an important physiological role in the negative regulation of cell-mediated immune responses. T. Sato presented an important discovery concerning the production of this protein at the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, DC.

"We show localization of IL-10 protein in metastatic melanomas and demonstrate that IL-10 is mainly produced by melanoma cells rather than...

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Source: Cancer Weekly (1996-05-06)

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