"Anti-Gene Therapy: Inhibition of Gene Expression by Ribozyme Therapeutics for the Treatment of Human Disease."

According to an abstract submitted by the authors at the annual meeting for the Association of American Physicians, American Society for Clinical Investigation, and American Federation for Clinical Research, entitled Biomedicine '96: Medical Research from Bench to Bedside, held May 3-6, 1996, in Washington DC, "Ribozymes are small, enzymatic RNA molecules that can catalyze a number of chemical reactions. Ribozymes can be readily engineered to specifically cleave any mRNA and thus inhibit expression of genes involved in pathogenesis of human disease. In some clinical settings, extracellular delivery of synthetic ribozymes can be contemplated. By way of example, proliferation of injured...

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