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Adenovirus-Mediated IL-2 Gene Therapy for Hepatocellular Carcinoma Promising

Published in Cancer Weekly, May 13th, 1996

Adenoviral-mediated interleukin 2 (IL-2) gene therapy shows promise in an murine model of hepatocellular carcinoma (HCC).

In order to explore gene therapy as a new treatment modality for HCC, Hanzian Huang et al., of the Baylor College of Medicine, established an orthotopic cancer model by intrahepatic implantation of a HCC cell line in syngeneic mice. Results were presented at the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, DC.

"In vivo IL-2 gene therapy is effective in treating both primary and metastatic hepatomas in the animal model," stated Huang et al. "This suggests that this...

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