"Immunoliposomes As Enzyme-Carriers (Immuno-Enzymosomes) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT): Optimization of Prodrug Activating Capacity. DOUBLE

According to the authors' abstract of an article published in Pharmaceutical Research, "Purpose: Immuno-enzymosomes are tumor-specific immunoliposomes bearing enzymes on their surface. These enzymes are capable of converting relatively nontoxic prodrugs into active cytostatic agents. The enzyme beta-glucuronidase (GUS)(4) was coupled to the external surface of immunoliposomes directed against ovarian carcinoma cells. This study aimed at optimization of the prodrug-activating capacity of these immuno-enzymosomes by increasing the enzyme density on the immunoliposomal surface. Methods: To achieve coupling of GUS to the liposomes, introduction of extra thiol groups was...

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