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Apoptosis Induced by Bcl-xS Gene Therapy in Breast Cancer Model

Published in Cancer Weekly, May 20th, 1996

bcl-xS gene therapy reduces tumor burden by 50 percent in a murine model of human mammary carcinoma.

bcl-2 and bcl-xL are genes which encode proteins which inhibit apoptosis and are overexpressed in a significant subset of human breast cancers. bcl-x short (bcl-xS) is a dominant negative repressor of bcl-2 and bcl-xL.

"We hypothesized that transient overexpression of large amounts of Bcl-xS would induce apoptosis in the absence of other insults," stated V.N. Sumantran at the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, D.C. "To test this,...

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Source: Cancer Weekly (1996-05-20)

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