Published in Cancer Weekly, May 20th, 1996
bcl-2 and bcl-xL are genes which encode proteins which inhibit apoptosis and are overexpressed in a significant subset of human breast cancers. bcl-x short (bcl-xS) is a dominant negative repressor of bcl-2 and bcl-xL.
"We hypothesized that transient overexpression of large amounts of Bcl-xS would induce apoptosis in the absence of other insults," stated V.N. Sumantran at the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, D.C. "To test this,...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.