"5-Methyltetrahydrofolate or 5-Formyltetrahydrofolic Acid to Modulate 5-Fluorouracil's Cytotoxic Activity In Vivo? A Phase II Study in Patients with Advanced Colon Cancer."

According to the authors' abstract of an article published in Cancer Chemotherapy and Pharmacology, "The purpose of this study was to test the hypothesis that 5-methyltetrahydrofolate (Me-THF), a source of reduced folates alternative to leucovorin, could effectively modulate 5-fluorouracil's (5-FU) cytotoxic activity in patients with advanced colon cancer. A total of 23 patients were enrolled in a phase II trial; they received 5-FU as a 30-min infusion at a dose of 370 mg/m² following a rapid i.v. push of 200 mg/m² Me-THF, both drugs being given for 5 consecutive days. Cycles were repeated every 4 weeks until disease progression. No patient achieved a complete...

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