Immunotherapy (Antitumor)
"Human Lymphocyte Responses to Autologous B7+ Tumour Cells In Vitro."
Published in Cancer Weekly, June 17th, 1996
According to an abstract submitted by the authors to the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, D.C., "Transfection of the costimulatory molecule B7-1 into murine tumours can increase antitumor immunity and eradicate tumour growth. The purpose of this study was to transduce freshly resected human cancers by infection with an adenovirus-B7 (Ad-B7) expression vector and test autologous lymphocyte responses against these B7+ cancer cells in vitro. Resected tumours were disaggregated into single cell suspensions by mechanical mincing and digestion with a collagenase-based enzymatic cocktail. The Ad-B7 vector, a...
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Source: Cancer Weekly (1996-06-17)
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