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Vectors (Immune Response)

Transfection of IL-10 Reduces the Anti-Vector Host Immune Response

Published in Cancer Weekly, July 15th, 1996

The addition of the immunosuppressive cytokine gene vIL-10 to an adenoviral vector reduces the effects of the host immune response against the vector.

Because of their broad host range, high titers, and capacity for large DNA inserts, adenoviral vectors are attractive for gene transfer. Unfortunately, their effectiveness is limited by host anti-viral immune responses.

J.S. Bromberg et al. presented data at the joint meeting of the American Society for Biochemistry and Molecular Biology, the American Society for Investigative Pathology, and the American Association of Immunologists, held June 2-6, 1996, in New Orleans, Louisiana, which showed that...

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