"Efficient Tumor Eradication by Adoptively Transferred Cytotoxic T-Cell Clones in Allogeneic Hosts."

According to the authors' abstract of an article published in International Journal of Cancer, "Tumor-specific cytotoxic T cells (CTLs) can play an important role against cancer as illustrated by the observation that adoptive transfer of tumor-specific CTLs can mediate potent anti-tumor effects. Although such CTLs can be detected at the tumor site, relatively little is known about the mechanisms by which they enter the tumor. In this study, the role of major histocompatibility complex (MHC) class I molecules on vascular endothelium in the tumor in entry of, and tumor eradication by, tumor-specific CTL was investigated. Two H-2D(b)-restricted CTL clones recognizing peptide VNIRNCCYI on...

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