Kaposi's sarcoma
"Expression and Cytokine Regulation of Glucocorticoid Receptors in Kaposi's sarcoma."
Published in Cancer Weekly, July 15th, 1996
According to the authors' abstract of an article published in American Journal of Pathology, "Development of Kaposi's sarcoma (KS) after glucocorticoid therapy has been observed in a variety of clinical states including human immunodeficiency virus-1 infection and recent in vitro studies provided evidence for a direct stimulatory effect of glucocorticoid hormones on KS cell proliferation. The importance of glucocorticoids in KS pathogenesis is further highlighted by the finding that glucocorticoids synergize with cytokines to promote acquired immune deficiency syndrome (AIDS)-associated KS (AIDS-KS) growth. Furthermore, cytokine effects were abrogated by the glucocorticoid antagonist...
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Source: Cancer Weekly (1996-07-15)
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