Published in Cancer Weekly, July 15th, 1996
Antisense oligonucleotides act by specifically hybridizing with complementary RNA sequences. They inhibit protein expression through a number of mechanisms including degradation of the targeted RNA through RNase H-mediated cleavage. Because of these properties, antisense oligonucleotides might have therapeutic value as antineoplastic agents when targeted to appropriate molecular targets and possibly prevent the initiation or progression of specific cancers.
Brett P. Monia et al....
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