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Breast Cancer (Therapy)

Update on Chemotherapy in Node-Negative, ER-Negative Cancer Patients

Published in Cancer Weekly, July 22nd, 1996

Data from the National Surgical Adjuvant Breast and Bowel Project (NSABP) indicated that chemotherapy does decrease the incidence of local-regional tumor recurrence and distant metastases in women with node-negative, estrogen-receptor-negative breast cancer.

Two protocols were evaluated in more than 1,800 women. The B-13 arm of the study evaluated the sequential administration of methotrexate followed by fluorouracil in 760 patients, while the B-19 arm compared sequential methotrexate-fluorouracil with conventional cyclophosphamide/methotrexate/fluorouracil (CMF) in 1,095 others. The report appeared in the July 1996 Journal of Clinical Oncology (J Clin Oncol...

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