DNA Vaccines (Hepatitis B)

DNA Vaccine for HBV Tested and Compared in Chimpanzee Model

Published in Cancer Weekly, July 29th, 1996

Vaccination against hepatitis B virus (HBV) by intramuscular injection of plasmid DNA encoding the major and middle HBV envelope proteins induced group-, subtype-, and preS2-specific antibodies in a chimpanzee model.

Empty 22-nm subviral particles purified from the plasma of chronic carriers were the first HBV vaccines to be used in humans. The second, and current generation of HBV vaccines consists of similar subviral particles which have been produced as recombinant proteins in stably transfected eukaryotic cell lines.

In spite of their high efficacy, the current subunit HBV vaccines are not widely used in developing countries owing to the high...

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Source: Cancer Weekly (1996-07-29)

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