Published in Cancer Weekly, August 5th, 1996
Few primary cervical cancers have inactivation of the p53 gene as a result of allelic loss or point mutation. Most cervical cancers are a result of the carcinogenic effects of human papillomavirus (HPV) types 16 and 18. In these cervical cancers, the E6 and E7 proteins of HPV 16 and 18 are frequently coexpressed. These proteins are necessary for immortalization of natural hosts cells, and the continued expression of these proteins seems to be necessary for maintaining the malignant phenotype.
It has also been shown that E7...
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